Real Results

PoNSTEP Study

Participants who maintained a strong adherence to PoNS Therapy (meaning that they consistently followed their therapy plan) had a statistically significant average improvement in their DGI.

50%

of participants who maintained 85-100% adherence to PoNS Therapy saw an improvement of nearly 7 points in DGI scores

74%

of those who maintained 70% adherence gained at least a 5-point improvement in DGI scores from baseline to end of treatment

Improvement in gait function from the 14-week treatment was maintained for at least 6 months after treatment completion.

14-Week RCT to Improve Gait in MS Patients

Individuals with MS consistently using PoNS with physical therapy (PT) improved gait scores by more than >2x vs individuals with MS using a sham device and physical therapy.

Of the Active PoNS Group achieved a statistically and clinically meaningful ≥4-point improvement on the DGI just two weeks into treatment.

Mean improvement score: 7.95 by the end of PoNS Therapy

100%

Of the Placebo Group achieved a ≥4-point improvement on the DGI at week 10 of treatment.

Mean improvement score: 3.45 after treatment completion.

30%

Real-World Evidence Database Analysis

A database analysis of Real-World Evidence showed both clinically and statistically significant improvements in participants’ functional gait assessment (FGA) scores.

Of individuals in the study achieved a clinically meaningful ≥4-point improvement in their FGA

58.3%

PoNS Clinical Data Presentation

One-On-One Support

PoNS Therapy is a comprehensive, one-on-one, 14-week program guided by a PoNS Trainer for the first two
weeks of treatment before training independently at home to complete their therapy.

A Portable Treatment

PoNS is portable, which means PoNS Therapy can be completed 91% of the time at home with occasional check-ins from your PoNS Trainer.

Tailored to You

Your PoNS Therapy program will be tailored to your needs. Therapeutic activities with PoNS may include:

Balance training
Gait training
Breathing and awareness training
Other neuro-rehabilitative exercises

PoNS Therapy Application

READY TO GET STARTED?

REFERENCES:

Backus, D., Langston, C., Yadav, V. J., Plummer, P., Charvet, L., Maislin, G., & Napoli, S. (2025, May). Long-term efficacy of translingual neurostimulation by a Portable Neuromodulation Stimulator on gait deficit improvement in multiple sclerosis: Results from PoNSTEP study [Conference abstract]. The Consortium of Multiple Sclerosis Centers (CMSC) Conference, Phoenix, AZ.
Helius Medical, Inc. Portable Neuromodulation Stimulator (PoNS) Real-World Evidence Study August 2, 2020.
Tyler ME, Kaczmarek KA, Rust KL, Subbotin AM, Skinner KL, Danilov YP. Non-invasive neuromodulation to improve gait in chronic multiple sclerosis: a randomized double-blind controlled pilot trial. J Neuroeng Rehabil. 2014;11:79. doi: 10.1186/1743-0003-11-79